Simvastatin inhibits CD44 fragmentation in chondrocytes.

Lipophilic Statins Inhibit CD44 Fragmentation In Chondrocytes

Chondroprotective Effect of Kartogenin on CD44-Mediated Functions in Articular Cartilage and Chondrocytes

OBJECTIVE A recent report identified the small molecule kartogenin as a chondrogenic and chondroprotective agent. Since changes in hyaluronan metabolism occur during cartilage degeneration in osteoarthritis, we began studies to determine whether there was a connection between extracellular hyaluronan, CD44-hyaluronan interactions and the effects of kartogenin on articular chondrocytes. METHOD...

Intracellular interaction of CD44 with Hyaluronidase-2 in chondrocytes

INTRODUCTION: Hyaluronan (HA) functions to retain aggrecan within cartilage. The HA/proteoglycan-rich cell-associated matrix is anchored to chondrocytes by HA binding to CD44, the principal cell surface receptor for HA. CD44 mediates the endocytosis of HA that results in HA catabolism intracellularly via the action of lysosomal hyaluronidases. The hyaluronidases are represented by a family of β...

Alterations in CD44 isoforms and HAS expression in human articular chondrocytes during the de- and re-differentiation processes.

The purpose of this study was to investigate the expression of different CD44 and hyaluronan synthase isoforms in cartilage, their alterations during the chondrocyte dedifferentiation process in monolayer culture and during the redifferentiation process on 3D scaffolds. Chondrocytes isolated from human articular cartilage were cultured as a monolayer for up to 36 days and were seeded on two dif...

Simvastatin prevents proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo.

OBJECTIVES To explore the mechanism about how HMG-CoA reductase (HMGR) inhibitor inhibit proliferation and bone metastases of lung adenocarcinoma in vitro and in vivo. METHODS The HMGR inhibitor simvastatin, human lung cancer cell line A549 and Balb/c nude mouse were used in this study. The mice were randomly divided into 2 groups: control group (0.9% NaCl solution, i.v.) and simvastatin grou...